27 September 2023

Update on feline infectious peritonitis: Antiviral drugs

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Update on feline infectious peritonitis

4. Treatment options Antiviral drugs Published 27 September 2023 | Updated 9 August 2024 The protease inhibitor, GC376, which is able to inhibit viral replication in feline infectious peritonitis (FIP) was shown to have some effect but was not able to achieve remission in all cats. The nucleoside analogues remdesivir and GS-441524 (the active form of the pro-drug remdesivir) have been legally available to vets in the UK for the treatment of FIP in cats since August 2021. The literature around these products has evolved rapidly and there are now longer term follow up studies and clinical trials being published. BSAVA members may be interested in the client information leaflets provided in the BSAVA Library.

GS-441524
Remdesivir

A Knowledge Summary, published in Veterinary Evidence, concludes that there is now moderate evidence that these products can extend the survival time of cats suffering from feline infectious peritonitis. Further evidence will be added to this section as it is published.

Mulligan, A. J. and Browning, M. E. (2024) Quality assessment and characterization of unregulated antiviral drugs for feline infectious peritonitis: implications for treatment, safety, and efficacy. American Journal of Veterinary Research. https://doi.org/10.2460/ajvr.23.10.0221
Kent, A. M. et al. (2024) Unlicensed antiviral products used for the at-home treatment of feline infectious peritonitis contain GS-441524 at significantly different amounts than advertised. Journal of the American Veterinary Medical Association. https://doi.org/10.2460/javma.23.08.0466

Knowledge Summary in vitro studies Case studies and case series Updated 24 January 2025 Clinical trials Updated 9 August 2024 Claiming CPD for reading inFOCUS articles Reading and reflecting on articles can count towards your CPD, and we have a template to help you with the process. Online full-text available to Library members A range of library membership packages is available and MRCVS vets and RVNs can join the library for a heavily subsidised, annual fee. spotlight topic:

Update on feline infectious peritonitis

4. Treatment options Antiviral drugs Published 27 September 2023 | Updated 15 March 2024 The protease inhibitor, GC376, which is able to inhibit viral replication in feline infectious peritonitis (FIP) was shown to have some effect but was not able to achieve remission in all cats. The nucleoside analogues remdesivir and GS-441524 (the active form of the pro-drug remdesivir) have been legally available to vets in the UK for the treatment of FIP in cats since August 2021. The literature around these products has evolved rapidly and there are now longer term follow up studies and clinical trials being published. BSAVA members may be interested in the client information leaflets provided in the BSAVA Library.

GS-441524
Remdesivir

Mulligan, A. J. and Browning, M. E. (2024) Quality assessment and characterization of unregulated antiviral drugs for feline infectious peritonitis: implications for treatment, safety, and efficacy. American Journal of Veterinary Research. https://doi.org/10.2460/ajvr.23.10.0221
Kent, A. M. et al. (2024) Unlicensed antiviral products used for the at-home treatment of feline infectious peritonitis contain GS-441524 at significantly different amounts than advertised. Journal of the American Veterinary Medical Association. https://doi.org/10.2460/javma.23.08.0466

Knowledge Summary in vitro studies Case studies and case series Clinical trials Claiming CPD for reading inFOCUS articles Reading and reflecting on articles can count towards your CPD, and we have a template to help you with the process. Online full-text available to Library members A range of library membership packages is available and MRCVS vets and RVNs can join the library for a heavily subsidised, annual fee.