27 February 2024
Stem cells – what is the evidence?
3. Regenerative medicine Published 26 February 2024 | updated 4 June 2025 Regenerative medicine is defined as the process of replacing or regenerating cells, tissues, or organs to restore or establish normal function, this may include the use of stem cells. This section includes references to the clinical use of stem cells in veterinary practice, while references relating to specific products are included in the section below.- Colomer-Selva, R. et. al. (2025) Physiological factors affecting platelet-rich plasma variability in human and veterinary medicine. Frontiers in Veterinary Science, 12. https://doi.org/10.3389/fvets.2025.1571373
- Del Prete, C. et al. (2024) Use of regenerative medicine in the treatment of endometritis in mares: A systematic review and meta-analysis. Theriogenology, 227, pp. 9-20. https://doi.org/10.1016/j.theriogenology.2024.07.006
- M’Cloud, W.R.C. et al. (2024) Stem cells and platelet-rich plasma for the treatment of naturally occurring equine tendon and ligament injuries: a systematic review and meta-analysis. Journal of the American Veterinary Medical Association. https://doi.org/10.2460/javma.23.12.0723
- Purbantoro, S.D. et al. (2024) Trends of regenerative tissue engineering for oral and maxillofacial reconstruction in veterinary medicine. Frontiers in Veterinary Science, 11, no. 1325559. https://www.frontiersin.org/articles/10.3389/fvets.2024.1325559
- Boone, L. and Peroni, J. (2023) Introduction to equine biologic and regenerative therapies. Veterinary Clinics: Equine Practice, 39 (3), pp. 419-427. https://doi.org/10.1016/j.cveq.2023.06.006
- Carr, B.J. (2023) Regenerative medicine and rehabilitation therapy in the canine. Veterinary Clinics: Small Animal Practice, 53 (4), pp. 801-827. https://doi.org/10.1016/j.cvsm.2023.02.011
- Pérez Fraile, A. et al. (2023) Regenerative medicine applied to musculoskeletal diseases in equines: A systematic review. Veterinary Sciences, 10 (12), no. 666. https://doi.org/10.3390/vetsci10120666
- Mayet, A., Zablotski, Y., Roth, S.P., Brehm, W. and Troillet, A., 2023. Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. Frontiers in Veterinary Science, 10, p.1125695. https://doi.org/10.3389/fvets.2023.1125695
- Everett, J.B. et al. (2023) Intra-articular bone marrow mononuclear cell therapy improves lameness from naturally occurring equine osteoarthritis. Frontiers in Veterinary Science, 10. https://doi.org/10.3389/fvets.2023.1256284
- Durgam, S., and Stewart, M. (2017) Evidence supporting intralesional stem cell therapy to improve equine flexor tendon healing. Veterinary Evidence, 2 (1). https://doi.org/10.18849/ve.v2i1.50